Anti-CD123 antibodies, anti-CD123 chimeric antigen receptors and anti-CD123 chimeric antigen receptors T cells

A monoclonal antibody that binds specifically to antigen CD123, wherein said monoclonal antibody comprises the complementarity determining regions of AB1, said monoclonal antibody having a KD value of 9.5×10−9 M, or less, an antibody dissociation rate koff of 9.0×10−4 s−1 or less, and an antibody association rate kon of 7×104 Ms−1, or greater, and

• comprises a heavy chain and a light chain, and wherein the heavy chain comprises a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
• 25, a complementarity determining region 2 (CDR2) comprising the amino acid sequence of SEQ ID NO:
• 13, and a complementarity determining region 3 (CDR3) comprising the amino acid sequence of SEQ ID NO:
• 1 and wherein the light chain comprises a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
• 26, a complementarity determining region 2 (CDR2) comprising the amino acid sequence of SEQ ID NO:
• 14, and a complementarity determining region 3 (CDR3) comprising the amino acid sequence of SEQ ID NO:2.