Anti-Sortilin antibodies and use thereof

An anti-sortilin antibody, or antigen-binding fragment thereof, comprising:

• (A)i. a heavy chain variable domain CDR1 comprising SEQ ID NO:
• 19;
• ii. a heavy chain variable domain CDR2 comprising SEQ ID NO:
• 20;
• iii. a heavy chain variable domain CDR3 comprising SEQ ID NO:
• 21;
• iv. a light chain variable domain CDR1 comprising SEQ ID NO:
• 22;
• v. a light chain variable domain CDR2 comprising SEQ ID NO:
• 23;
• and
• vi. a light chain variable domain CDR3 comprising SEQ ID NO:
• 24, or
• (B) a heavy chain variable domain comprising SEQ ID NO:
• 115;
• and
• a light chain variable domain comprising SEQ ID NO:
• 116.