Methods of identifying and evaluating cat allergy gene signatures in a subject by determining a stratified score based on gene expression
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsMatthew F. Wipperman, Kaitlyn Gayvert, Wei Keat Lim, Jennifer D. Hamilton, Sara C. Hamon, Meagan O'Brien
Life of this patent
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Abstract
The present disclosure provides methods of identifying a subject as suitable for the treatment or prevention of asthma exacerbation induced by a cat allergen with at least one antibody to the cat allergen. The present disclosure also provides methods of treating a subject having asthma exacerbation induced by a cat allergen or preventing a subject from developing asthma exacerbation induced by a cat allergen by administering at least one antibody to the cat allergen to the subject.
Claims10
A method of identifying a subject as suitable for the treatment or prevention of asthma exacerbation induced by a cat allergen with at least one antibody to the cat allergen, the method comprising:
- a) generating or having generated a first transcriptome for the subject;
- b) exposing the subject to at least one cat allergen;
- c) generating or having generated a second transcriptome for the subject after exposure to the at least one cat allergen;
- and
- d) screening the second transcriptome against the first transcriptome to generate a cat allergen exposure transcriptome;
- wherein the subject is suitable for the treatment or prevention of asthma exacerbation induced by a cat allergen with at least one antibody to the cat allergen when the cat allergen exposure transcriptome comprises:
- a downregulation of at least any ten of the following genes:
- CCDC33, ADH6, IFLTD1, DLGAP1-AS5, DNAJB13, C2orf62, CCDC81, PIH1D3, NHLRC4, TMEM190, AK090700, KIF6, BBOX1, PTGFR, SEC14L3, BC022056, CASC2, PPP1R36, CNTN5, KLHDC8A, FHOD3, CAPS, UBD, TP73, BC023516, IFI44L, FAM86B1, CX3CL1, ACY3, MPDZ, IGFBP5, AK097288, IFI6, ABCC6, GAS1, and PLCH1;
- and
- an upregulation of at least any twenty of the following genes:
- ESPL1, NMU, CTSL2, CLIC3, CRABP2, AX746775, TMPRSS11A, NCCRP1, MSX2, HSP90AB4P, AIMIL, SERPINB2, ILIRN, KLK10, PXDN, HSPB8, CLCA4, KRT10, ZBED2, DSC2, LY6G6C, ADAMTSL4, OTOP3, FGFBP1, GPR115, TRPV3, CRISP3, SPRR3, PRSS3, A2ML1, SPINK7, LYPD3, RHCG, SPRRIA, MAP2, S100A8, RPTN, PRSS27, KRT6B, PPP2R2C, ILIRL1, CAMK2N1, CPA4, KLK13, SERPINB13, ALOX12, SLC39A2, KRT4, HOPX, FAM25A, EMP1, CNFN, KLK12, APOBEC3A, CAPN14, IVL, KLK8, SPRRIB, IGFBP6, IL36G, KLK7, EGR3, KRT78, CRNN, MAL, LINC00707, KRT24, KRT6A, TMPRSS11B, KRT14, PRB3, KRT13, LOC731424, and BCL2L2-PABPN1.
Dependencies are inferred from the claim text.