Anti-human immunodeficiency virus-1 antibodies and methods for uses thereof
AssigneeGrifols Diagnostic Solutions Inc.
InventorsElisabete Nascimento, Jody Melton Witt
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Abstract
An anti-HIV-1 antibody includes L-CDR1, L-CDR2 and L-CDR3. L-CDR1 is one of SEQ ID NO: 15, SEQ ID NO: 18, SEQ ID NO: 21, and a sequence that differs from SEQ ID NOs: 15, 18, or 21 by one or two substitutions, deletions, or additions. The amino acid sequence of L-CDR2 is one of SEQ ID NO: 16, SEQ ID NO: 19, SEQ ID NO: 22, and a sequence that differs from SEQ ID NOs: 16, 19, or 22 by one or two substitutions, deletions, or additions. The amino acid sequence of L-CDR3 is one of SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 23, and a sequence that differs from SEQ ID NOs: 17, 20, or 23 by one or two substitutions, deletions, or additions.
Claims20
An anti-HIV-1 antibody or fragment thereof comprising a light chain comprising complementary determining regions L-CDR1, L-CDR2 and L-CDR3 and a heavy chain comprising complementary determining regions H-CDR1, H-CDR2 and H-CDR3, wherein the L-CDR1, L-CDR2, L-CDR3, H-CDR1, H-CDR2 and H-CDR3 are selected from the group consisting of (a), (b), and (c) below:
- (a) the amino acid sequence of L-CDR1 comprises SEQ ID NO:
- 18,
- the amino acid sequence of L-CDR2 comprises SEQ ID NO:
- 19,
- the amino acid sequence of L-CDR3 comprises SEQ ID NO:
- 20,
- the amino acid sequence of H-CDR1 comprises SEQ ID NO:
- 27,
- the amino acid sequence of H-CDR2 comprises SEQ ID NO:
- 28,
- the amino acid sequence of H-CDR3 comprises SEQ ID NO:
- 29,
- (b) the amino acid sequence of L-CDR1 comprises SEQ ID NO:
- 15,
- the amino acid sequence of L-CDR2 comprises SEQ ID NO:
- 16,
- the amino acid sequence of L-CDR3 comprises SEQ ID NO:
- 17,
- the amino acid sequence of H-CDR1 comprises SEQ ID NO:
- 24,
- the amino acid sequence of H-CDR2 comprises SEQ ID NO:
- 25,
- the amino acid sequence of H-CDR3 comprises SEQ ID NO:
- 26,
- (c) the amino acid sequence of L-CDR1 comprises SEQ ID NO:
- 21,
- the amino acid sequence of L-CDR2 comprises SEQ ID NO:
- 22,
- the amino acid sequence of L-CDR3 comprises SEQ ID NO:
- 23,
- the amino acid sequence of H-CDR1 comprises SEQ ID NO:
- 30,
- the amino acid sequence of H-CDR2 comprises SEQ ID NO:
- 31,
- the amino acid sequence of H-CDR3 comprises SEQ ID NO:
- 32.
An anti-HIV-1 antibody, which specifically binds to an epitope of HIV-1 p24 protein consisting of an amino acid sequence of SEQ ID NO:
- 33, wherein the anti-HIV-1 antibody comprises a light chain comprising complementary determining regions L-CDR1, L-CDR2 and L-CDR3 and a heavy chain comprising complementary determining regions H-CDR1, H-CDR2 and H-CDR3,
- wherein
- the amino acid sequence of L-CDR1 comprises SEQ ID NO:
- 21,
- the amino acid sequence of L-CDR2 comprises SEQ ID NO:
- 22,
- the amino acid sequence of L-CDR3 comprises SEQ ID NO:
- 23,
- the amino acid sequence of H-CDR1 comprises SEQ ID NO:
- 30,
- the amino acid sequence of H-CDR2 comprises SEQ ID NO:
- 31,
- the amino acid sequence of H-CDR3 comprises SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.