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US 12,747,272 B2Granted
Compositions and methods for selective protein degradation
AssigneeNovartis AG
InventorsSeth Carbonneau, Marc Horst Peter Hild, Andrei Golosov, Nicole Renaud
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Abstract
The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a degradation polypeptide and a heterologous polypeptide of interest.
Claims27
A fusion polypeptide comprising a degradation polypeptide and a heterologous polypeptide, wherein
- the degradation polypeptide comprises the amino acid sequence of FQCEICGFSCR (SEQ ID NO:
- 1584) or FQCEICGASFR (SEQ ID NO:
- 1624).
Dependencies are inferred from the claim text.