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US 12,747,261 B2Granted
MRNA 5′-end cap analogs modified within phosphate residues, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide
AssigneesUniwersytet Warszawski, Explorna Therapeutics Sp. z o.o.
InventorsMarcin Warminski, Pawel Sikorski, Joanna Kowalska, Jacek Jemielity
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Abstract
The invention relates to new 5′mRNA end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method translates the RNA molecule.
Claims9
A compound selected from the group consisting of
- (a) compound m7Gppp5′SApG of formula
- (b) compound m7Gppp5′SAmpG of formula
- and
- (c) a compound of formula (I)
- wherein:
- R2 is H, R3 is H,
- R1 is selected from the group consisting of:
- H, CH3, alkyl,
- Base1 is selected from the group consisting of:
- wherein R4 is selected from the group consisting of:
- H, CH3, alkyl, alkenyl, alkynyl, and alkylaryl,
- X1 is O,
- X3 is O or S,
- X2 is O or S,
- X4 is O or S,
- X5 is O or CH2,
- wherein X4 is S, X5 is CH2, or both.
14 more elements
Dependencies are inferred from the claim text.