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US 12,747,257 B2Granted
Polyhydroxylated cyclopentane derivatives and methods of use
AssigneeSanegene Bio USA Inc.
InventorsWeimin Wang, Xiaochuan Cai
Life of this patent
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Abstract
The present disclosure provides linker compounds of Formula (I) or (II): pharmaceutically acceptable salts thereof, and related scaffolds and conjugates. The present disclosure also relates to uses of the linker compounds, scaffolds, and conjugates, e.g., in delivering nucleic acid and/or treating or preventing diseases.
Claims19
A conjugate, or a pharmaceutically acceptable salt thereof, wherein the conjugate comprises:
- (i) one or more Nucleic Acid Agents;
- and
- (ii) one or more moieties selected from:
- wherein:
- Y is H, C1-C6 alkyl optionally substituted with one or more halogen, —P(RY)2, —P(ORY)(N(RY)2), —P(═O)(ORY)RY, —P(═S)(ORY)RY, —P(═O)(SRY)RY, —P(═S)(SRY)RY, —P(═O)(ORY)2, —P(═S)(ORY)2, —P(═O)(SRY)2, —P(═S)(SRY)2, or a hydroxy protecting group;
- each RY independently is H or C1-C6 alkyl optionally substituted with one or more halogen or cyano;
- Z is H, or C1-C6 alkyl optionally substituted with one or more halogen, —P(RZ)2, —P(ORZ)(N(RZ)2), —P(═O)(ORZ)RZ, —P(═S)(ORZ)RZ, —P(═O)(SRZ)RZ, —P(═S)(SRZ)RZ, —P(═O)(ORZ)2, —P(═S)(ORZ)2, —P(═O)(SRZ)2, —P(═S)(SRZ)2, or a hydroxy protecting group;
- each RZ independently is H or C1-C6 alkyl optionally substituted with one or more halogen or cyano;
- and each ## independently indicates an attachment to the rest of the conjugate.
6 more elements
Dependencies are inferred from the claim text.