Orexin receptor agonists and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein
• n and m are independently 0 or 1;
• A1 is —O—, —CR4R5—, —NR6—, —S— or a bond;
• A2 is —C(O)— or —S(O)2—;
• A3 and A4, are independently —O—, —CR4R5—, —NR6, —S— or a bond;
• or A3 and A4 together are —C(R4)═C(R5)—;
• A5 and A6 are independently —O—, —CR4R5—, —NR6, —S— or a bond;
• with the proviso that the ring that includes A2, A3, A4, A5 and A6 does not contain —O—O—, —NR6—NR6— or —O—NR6—;
• L1 is —O—, —CR4R5— or a bond;
• L2 is —CR4R5;
• R1 is a alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(C═O)alkyl, —(C═O)cycloalkyl, —(C═O)heterocyclyl, —(C═O)aryl, —(C═O)heteroaryl, —(C═O)—O-alkyl, —(C═O)—O-cycloalkyl, —(C═O)—O-heterocyclyl, —(C═O)—O-aryl, —(C═O)—O-heteroaryl, —S(O)2-alkyl, —S(O)2-cycloalkyl, —S(O)2-heterocyclyl, —S(O)2-aryl, —S(O)2-heteroaryl or —(C═O)NR7R8, or R1 and R2 together with the atom to which they are attached form a heterocycle or heteroaryl;
• R2 and R3 are independently hydrogen, halogen, alkyl, cycloalkyl or heterocyclyl, or R2 and R3 together with the atom to which they are attached form a carbocycle or heterocycle;
• R4 and R5 are independently hydrogen, alkyl, cycloalkyl, heterocyclyl, alkoxy, —O-cycloalkyl, —O-heterocyclyl or halogen, or R4 and R5 together with the atom to which they are attached to form a carbocycle or heterocycle;
• R6 is hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(C═O)alkyl, —(C═O)cycloalkyl, —(C═O)heterocyclyl, —(C═O)aryl, —(C═O)heteroaryl, —(C═O)—O-alkyl, —(C═O)—O-cycloalkyl, —(C═O)—O-heterocyclyl, —(C═O)—O-aryl, —(C═O)—O-heteroaryl, —S(O)2-alkyl, —S(O)2-cycloalkyl, —S(O)2-heterocyclyl, —S(O)2-aryl, —S(O)2-heteroaryl or —(C═O)NR7R8,
• R7 and R8 are independently hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, or R7 and R8 together with the atom to which they are attached to form a heterocycle;
• Y is cycloalkyl, heterocyclyl, heteroaryl or aryl;
• and
• Z is absent, heteroaryl or aryl.