Inhibitor of BTK and mutants thereof

A compound of Formula (I), or an N-oxide thereof, or a pharmaceutically acceptable salt, solvate, polymorph, tautomer, stereoisomer, an isotopic form, or a prodrug of said compound of Formula (I) or N-oxide thereof:

• wherein
• Q0 is a 5-9 membered aryl or heteroaryl;
• Q1 is a 5-9 membered aryl or heteroaryl;
• Q2 is a 5-7 membered heterocycloalkyl;
• Q3 is a 5-membered heteroaryl;
• Q4 is a 6-membered heteroaryl;
• W is —C(O)—, or —S(O2)—;
• Z is NH or O;
• Warhead is
• each of R0, R1, R5, R6, R7, R8, R9, and R10, independently, is H, D, alkyl, spiroalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, spiroheterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, halo, nitro, oxo, cyano, ORa, SRa, alkyl-Ra, NH(CH2)pRa, C(O)Ra, S(O)Ra, SO2Ra, C(O)ORa, OC(O)Ra, NRBRc, C(O)N(Rb)Rc, N(Rb)C(O)Rc, —P(O)RbRc, -alkyl-P(O)RbRc, —S(O)(═N(Rb))Rc, —N═S(O)RbRc, ═NRb, SO2N(Rb)Rc, or N(Rb)SO2Rc, in which said cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl are optionally substituted with one or more Ra;
• R3 is H, halo, alkyl, haloalkyl, or hydroxyalkyl;
• R4 is H, halo, or low alkyl;
• or
• R0 and R1 groups, taken together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl optionally substituted with one or more Ra;
• or
• two R1 groups, taken together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl optionally substituted with one or more Ra;
• or
• two R5 groups, taken together with the atom to which they are attached, form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl optionally substituted with one or more Ra;
• or
• two R6 groups, taken together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl optionally substituted with one or more Ra;
• or
• two R7 groups, taken together with the atom to which they are attached, form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl optionally substituted with one or more Ra;
• Ra, Rb, Rc and Rd, independently, is H, D, alkyl, spiroalkyl, alkenyl, alkynyl, halo, cyano, amine, nitro, hydroxy, ═O, C(O)NHOH, C(O)OH, C(O)NH2, alkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylamino, alkylamino, oxo, halo-alkylamino, cycloalkyl, cycloalkenyl, heterocycloalkyl, spiroheterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl, in which said alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, and heteroaryl optionally substituted with one or more Re;
• Re is H, D, alkyl, spiroalkyl, alkenyl, alkynyl, halo, cyano, amine, nitro, hydroxy, ═O, C(O)NHOH, alkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylamino, alkylamino, oxo, halo-alkylamino, cycloalkyl, cycloalkenyl, heterocycloalkyl, spiroheterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl;
• or
• two Rd groups, taken together with the atom to which they are attached, form a cycloalkyl or heterocycloalkyl optionally substituted with one or more Re;
• and
• each of i, j, m, n, and p, independently, is 0, 1, 2, 3, or 4.