Fused cyclic compound as Wee-1 inhibitor, preparation method therefor and use thereof

A compound of general formula (1) or an optical isomer, a crystalline form, a pharmaceutically acceptable salt, a hydrate or a solvate thereof:

• wherein in general formula (1):
• m is 0 or 1;
• R1 is H or halogen;
• R2 is H, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, halogenated C1-C6 alkyl, C1-C6 alkyl substituted with CN, C1-C6 alkyl substituted with OH, C1-C6 alkyl substituted with C1-C3 alkoxy, C1-C6 alkyl substituted with C3-C6 cycloalkyl or 4- to 7-membered heterocycloalkyl;
• R3 is H or C1-C3 alkyl;
• A is aryl or heteroaryl, wherein the aryl and heteroaryl are optionally substituted with 1 to 3 R6, each R6 is independently H, halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, halogenated C1-C6 alkyl, halogenated C1-C6 alkoxy, C1-C6 alkyl substituted with OH, C1-C6 alkyl substituted with cyano, halogenated C3-C6 cycloalkyl, C3-C6 cycloalkyl substituted with hydroxy, C3-C6 cycloalkyl substituted with cyano, C3-C6 cycloalkyl substituted with CF3, —NR7aR7b, —N═S(O)R7aR7b, —P(O)R7aR7b, —S(O)2R7a, —S(O)2NR7aR7b, —NR8P(O)R7aR7b, —NR8S(O)2R7a, —NR8C(O)R7a, —N═S(═NR8)R7aR7b or pyridonyl;
• R7a and R7b are independently C1-C3 alkyl, deuterated C1-C3 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, or R7a and R7b together with the nitrogen, sulfur or phosphorus atom attached thereto, form 3- to 10-membered heterocycloalkyl;
• R8 is H or C1-C3 alkyl, or R8 and R7a, together with the nitrogen and sulfur atoms or nitrogen and carbon atoms attached thereto, form 3- to 10-membered heterocycloalkyl;
• B is partially unsaturated C5-C7 cycloalkyl or partially unsaturated 5- to 7-membered heterocycloalkyl.