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US 12,747,238 B2Granted
Compounds for treatment of excitotoxicity
AssigneeNyrada Pty Ltd
InventorsPhillip Coghlan, Benny Evison, Jasneet Parmar
Life of this patent
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Abstract
The present invention relates to modulators of canonical-type of transient receptor potential (TRPC) channels, compositions thereof, and methods therewith. The present invention also relates to methods of treating TRPC mediated conditions using such modulators.
Claims9
A compound of Formula I, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:
- wherein:
- G1 is O or S;
- G2 is CR2 or N;
- R1 is
- R2 is selected from H, D, halo, hydroxy, amino, cyano, and C1-C4alkyl;
- R3 is:
- and
- R8 and R9 together with the N atom between them form an optionally substituted ring;
- wherein the ring formed by R8 and R9 and the N atom between them comprises 3-9 ring atoms.
6 more elements
A compound or a pharmaceutically acceptable salt, solvate or stereoisomer thereof of Formula II:
- wherein
- A1, A2 and A3 are selected from N, CH and CF;
- X is selected from O and S;
- G is selected from N and CR10;
- R10 is H, D, halo, C1-C4alkyl, hydroxy, amino, C1-C4alkyl, C1-C4alkoxy, C1-C4fluoroalkyl, phenyl, cyano, C1-C4thioalkyl, or C1-C4alkylamino;
- where R11 and R12 together with the N atom between them form a ring comprising 3-9 ring atoms.
3 more elements
A compound or a pharmaceutically acceptable salt, solvate or stereoisomer thereof selected from the group consisting of:
Dependencies are inferred from the claim text.