Kinase inhibitors for the treatment of neurodegenerative diseases

A compound having a structure represented by a formula:

• wherein each of R1a and R1b are independently selected from hydrogen, C1-C8 nitrile, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 haloalkyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, heteroaryl, and aryl;
• wherein each of R2a, R2b, R2c, R2d, and R2e are independently selected from hydrogen, halo, hydroxy, nitro, azido, —SF5, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 aminoalkyl, C1-C3 hydroxyalkyl, and —(C1-C3 alkanediyl)-NR5aR5b;
• wherein each occurrence of R5a and R5b is independently selected from hydrogen, C1-C3 alkyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl and heteroaryl;
• wherein A is a structure represented by a formula:
• wherein each of R3a and R3b is selected from hydrogen, halo, hydroxy, nitro, amino, azido, —SF5, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 aminoalkyl, and C1-C3 hydroxyalkyl;
• wherein Q3 is NR4c, CR4c, or O;
• wherein R4c is selected from hydrogen, halo, hydroxy, nitro, azido, —SF5, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 aminoalkyl, C1-C3 hydroxyalkyl, and —(C0-C3 alkanediyl)-NR5aR5b;
• wherein Z is selected from —O—, —S—, and —NR6—;
• wherein R6 is selected from hydrogen and C1-C3 alkyl;
• or a pharmaceutically acceptable salt thereof.