Compounds and methods of inhibiting bacterial chaperonin systems

A compound of formula Ia

• wherein
• R1 is
• R2 is halo,
• R3 is —OH or —O—C1-C6 alkyl;
• R4 is halo;
• R5 is H, —OH, halo, C1-C6 alkyl, —O—C1-C6 alkyl, —NO2, or —NH2;
• R6 is halo;
• R7 is C1-C6 alkyl;
• R8 is chloro;
• X is —C(H)(CN)—;
• and
• n is 0, 1, or 2;
• or a pharmaceutically acceptable salt thereof, provided the compound is not

A method of killing or inhibiting the growth of bacteria, said method comprising contacting the bacteria with a compound of the formula Ia

• wherein
• R1 is —OH, —OC1—C6 alkyl, —NHC(O)C1-C6 alkyl, —C(O)OC1—C6 alkyl, —C(O)OH, C1-C6 alkyl, or
• wherein each hydrogen atom in C1-C6 alkyl is optionally substituted by —CN,
• R2 is H or halo,
• each of R3, R4, R5, and R6 is independently H, —OH, halo, —O—C1-C6 alkyl, —NO2, or —NH2,
• R7 is H or C1-C6 alkyl,
• X is —O—, —S—, —C(R9)(R10)m—, or —C(R9)(R10)mO—,
• R8 is halo,
• R9 is H or —CN,
• R10 is H or —CN,
• m is 1 or 2, and
• n is 0, 1, or 2;
• or a pharmaceutically acceptable salt thereof, provided the compound is not