Imidazole-based synthetic lipidoids for in vivo mRNA delivery into immune cells

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• is selected from the group consisting of
• RLipid is independently represented by a structure of formula (II):
• further wherein:
• R1 and R2 are independently H, methyl, OH, NHR30, or SH;
• R3 and R4 are both H;
• or R3 and R4 are taken together to form an oxo (═O) group;
• Z is O, NR30, or S;
• X and Y are independently CH2, NR30, O, S, or Se;
• m is an integer selected from 1-3;
• n is an integer selected from 1-14;
• p is 0 or 1;
• q is an integer selected from 1-10;
• t is 0 or 1;
• and
• R30 is H, C1-6 alkyl, unsubstituted C1-6 alkenyl, or unsubstituted C1-6 alkynyl.