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US 12,747,213 B2Granted
Membrane-active anti-bacterial compounds and uses thereof
AssigneesTrustees of Dartmouth College, Regents of the University of Minnesota
InventorsAmbrose Cheung, Courtney Aldrich, John Schultz
Life of this patent
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Abstract
In an embodiment, the present disclosure pertains to methods of inhibiting bacterial growth. Generally, the methods include exposing bacteria to an anti-bacterial compound as disclosed herein. In some embodiments, the exposing occurs in vivo in a subject in order to treat or prevent a bacterial infection. In additional embodiments, the present disclosure pertains to anti-bacterial compounds that are suitable for inhibiting bacterial growth.
Claims10
A method of inhibiting bacterial growth in a subject, said method comprising:
- administering an anti-bacterial compound to the subject, wherein the anti-bacterial compound is:
- wherein Y2 is selected from the group consisting of H, F, chloro, —CHF2, —CH2F, —CF3, —OCF3, —OMe, —S(O)2N(Me)2, —C(═O) OH, tetrazolyl, azido, cyano, nitro, thiomethyl, methoxy, alkyl(C1-C4) ester, alky(C1-C4), phenyl, cyclohexyl, pyridin-2-yl, 3,4-dichloroanilino, 3,4-difluoroanilino, 3-(trifluoromethoxy) aniline, 5-(trifluoromethyl)pyridin-2-yl-amino, 5-(fluoro)pyridin-2-yl-amino, 5-dimethylaminopyridin-2-yl-amino, 6-(trifluoromethyl)pyridazine-3-yl-amino, pyridazine-3-yl-amino, pyridazine-3-yl, (N,N-dimethyl-6-sulfamoyl)pyridin-2-yl-amino, 1H-indazol-4-yl-amino, 4-(trifluoromethyl)cyclohexyl-amino, pyrrol-2-yl, pyrrol-3-yl, pyrrol-2-ylamino, 1-methylpyrrol-2-yl, 1-methylpyrrol-3-yl, 1-methylpyrrol-2-ylamino, morpholino, piperazinyl, and —N(Me)-R4;
- wherein R2 is selected from the group consisting of H, F, chloro, —CHF2, —CH2F, —CF3, —OCF3, —OMe, —S(O)2N(Me)2, —C(═O) OH, tetrazolyl, azido, cyano, nitro, thiomethyl, methoxy, alkyl(C1-C4) ester, alky(C1-C4), phenyl, 3,4-dichloroanilino, 3,4-difluoroanilino, 3-(trifluoromethoxy) aniline, 5-(trifluoromethyl)pyridin-2-yl-amino, 5-(fluoro)pyridin-2-yl-amino, 5-dimethylaminopyridin-2-yl-amino, 6-(trifluoromethyl)pyridazine-3-yl-amino, pyridazine-3-yl-amino, (N,N-dimethyl-6-sulfamoyl)pyridin-2-yl-amino, 1H-indazol-4-yl-amino, 4-(trifluoromethyl)cyclohexyl-amino, pyrrol-2-yl, pyrrol-3-yl, pyrrol-2-ylamino, 1-methylpyrrol-2-yl, 1-methylpyrrol-3-yl, 1-methylpyrrol-2-ylamino, morpholino, and piperazinyl;
- wherein R4 is selected from the group consisting of 5-(trifluoromethyl)pyridin-2-yl, phenyl, and cycloalkyl, and
- wherein the bacteria comprise Gram-positive (Gram+) bacteria.
2 more elements
Dependencies are inferred from the claim text.