US 12,747,209 B2 · Substituted diaryl compound as well as preparation method and application thereof

Abstract

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound shown as a formula (I), a preparation method of the substituted diaryl compound, a medicinal preparation containing the substituted diaryl compound and medical application of the substituted diaryl compound. Pharmacological test results show that the substituted diaryl compound disclosed by the invention has a good inhibition effect on cells of human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO). The formula (I) is shown in the specification.

Claims6

Dependent claims

A compound of general formula (I), or its pharmaceutically acceptable salt or its optical isomer,

wherein, R1 represents —OC2H5, —H, —CH(CH3)2, —Br, —CF3, —OCH3, —F, —Cl, or —CH3;
R2 represents —F, —CF3, —Br, —NHCOCH3, —C1, —H, —OCH3, or —CH(CH3)2;
R3 represents —H, —CH3, —C1, —Br, —NHCOCH3, —C3H7, —F, —C14H29, or —OCH3;
R4 represents —H, —Br, —CF3, or —Cl;
R5 represents —H, —Cl, —I, or —Br;
R6 represents

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/540,293Filed 14 Dec 2023 · continuation

Priority

CN 202110658765.415 Jun 2021

Published

US 2024/0166602 A123 May 2024

Granted

29 Sep 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 211/14
With radicals containing only carbon and hydrogen atoms attached to ring carbon atoms: with hydrocarbon or substituted hydrocarbon radicals…
A61P 35/00
Antineoplastic agents
C07C 217/58
With amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further…:…
C07C 217/64
Having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms…:…

Substituted diaryl compound as well as preparation method and application thereof

Life of this patent

Substituted diaryl compound as well as preparation method and application thereof

Life of this patent

Abstract

Claims6