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US 12,747,208 B2Granted
Pharmaceutical compounds and methods of making and using the same
AssigneeAthos Therapeutics, Inc.
InventorsDimitrios Iliopoulos, David G. Ho, Iordanis Karagiannidis, Phithi Nguyen, Dimitra Chalkia
Life of this patent
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Abstract
Disclosed herein are compounds (e.g., pyrrole compounds, carboxy pyrroles, etc.), including pharmaceutical compositions that include one or more of such compounds (e.g., carboxy pyrroles). Also disclosed are methods of making carboxy pyrrole compounds. Also disclosed herein are methods of treating diseases and/or conditions (e.g., inflammation and/or cancer) with the carboxy pyrrole compounds disclosed herein.
Claims20
A compound, or a pharmaceutically acceptable salt thereof, having a structure represented by Formula I:
- wherein:
- V, W, X, Y, and Z are each independently selected from the group consisting of C, C(R5), N, and NR6 and at least one instance of V, W, X, Y, and Zis N or NR6 with the remaining variables being C or C(R5);
- R1 is selected from the group consisting of optionally substituted C1-3 alkylene, optionally substituted 3-12 membered heterocyclyl, —NR7—, or R1 is not present;
- R2 is selected from the group consisting of —H, alkyl,
- and
- R3 is selected from the group consisting of optionally substituted C1-3 alkylene, —NR7—, —C(═O)—, —C(═O)NH—, and —C(═O)NR7—, or R3 is not present;
- R4 is selected from the group consisting of
- and
- each instance of R5, R6 and R7, where present, is independently selected from the group consisting of —H, halogen, hydroxy, C1-6 alkyl, C1-C6 alkoxy, C1-6 haloalkyl, optionally substituted C6-10 aryl, optionally substituted C6-10 benzyl, and optionally substituted C3-7 carbocyclyl;
- wherein when W is NR6, R4 is selected from the group consisting of
- and
- wherein when X is NR6, R2 is selected from the group consisting of —H, alkyl,
- and
- R4 is selected from the group consisting of
11 more elements
A compound, or a pharmaceutically acceptable salt thereof, having a structure represented by Formula I:
- wherein:
- V, W, X, Y, and Z are each independently selected from the group consisting of C, C(R5), N, and NR6 and at least one instance of V, W, X, Y, and Zis N or NR6 with the remaining variables being C or C(R5);
- R1 is selected from the group consisting of:
- R2 is either not present or is selected from the group consisting of-H, —OH, optionally substituted alkyl, optionally substituted N-amido, optionally substituted C6-10 aryl, 5-10 optionally substituted heteroaryl, optionally substituted C6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted 3-10 membered carbocyclyl, and optionally substituted 3-12 membered heterocyclyl, or R2 is not present;
- R3 is selected from the group consisting of optionally substituted C1-3 alkylene, —NR7, —C(—O)—, —C(═O)NH—, and —C(═O)NR7—, or R3 is not present;
- R4 is selected from the group consisting of optionally substituted C6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted 3-10 membered heterocyclyl, and optionally substituted C1-6 alkyl, or R4 is not present;
- and
- each instance of R5, R6 and R7, where present, is independently selected from the group consisting of —H, halogen, hydroxy, C1-6 alkyl, C1-C6 alkoxy, C1-6 haloalkyl, optionally substituted C6-10 aryl, optionally substituted C6-10 benzyl, and optionally substituted C3-7 carbocyclyl.
5 more elements
A compound, or a pharmaceutically acceptable salt thereof, having a structure represented by Formula I:
- wherein:
- V, W, X, Y, and Z are each independently selected from the group consisting of C, C(R5), N, and NR6 and at least one instance of V, W, X, Y, and Z is N or NR6 with the remaining variables being C or C(R5);
- R1 is selected from the group consisting of optionally substituted C1-3 alkylene, optionally substituted 3-12 membered heterocyclyl, —NR7—, or R1 is not present;
- R2 is an optionally substituted N-amido represented by:
- R3 is selected from the group consisting of optionally substituted C1-3 alkylene, —NR7—, —C(═O)—, —C(═O)NH—, and —C(═O) NR7—, or R3 is not present;
- R4 is selected from the group consisting of optionally substituted C6-10 aryl, optionally substituted 5-10 membered heteroaryl, optionally substituted 3-10 membered heterocyclyl, and optionally substituted C1-6 alkyl, or R4 is not present;
- and
- each instance of R5, R6 and R7, where present, is independently selected from the group consisting of —H, halogen, hydroxy, C1-6 alkyl, C1-C6 alkoxy, C1-6 haloalkyl, optionally substituted C6-10 aryl, optionally substituted C6-10 benzyl, and optionally substituted C3-7 carbocyclyl.
5 more elements
Dependencies are inferred from the claim text.