Parameter variation in neural stimulation
AssigneeCala Health, Inc.
InventorsAlexander R. Kent, Kathryn H. Rosenbluth, Gregory T. Schulte, Jessica M. Liberatore, Samuel Richard Hamner
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Abstract
Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and/or experience relating to the same.
Claims21
A method of generating jitter variation of nerve stimulation in a non-implantable wrist-worn device to enhance therapeutic response for a user, the method comprising:
- measuring a pathological tremor frequency of a tremor of the user;
- calculating or setting a treatment frequency that is different from the pathological tremor frequency to avoid exact alignment to the pathological tremor frequency,
- wherein the treatment frequency comprises a burst frequency and a burst frequency variation,
- wherein the burst frequency is centered around the pathological tremor frequency of the user, wherein the burst frequency variation varies by less than 6 Hz from the measured pathological tremor frequency of the user;
- and
- treating the user's tremor by stimulating at least two nerves, using at least two electrodes,
- wherein the at least two electrodes are located on the wrist-worn device,
- wherein the at least two electrodes are non-implantable,
- wherein the stimulating is performed using the treatment frequency,
- wherein at least one of (i) the burst frequency is jittered at a rate between 0.01 Hz/s and 0.1 Hz/s or (ii) a pulse frequency of the treatment frequency is jittered at a rate between 1 Hz/s and 10 Hz/s, and
- wherein the jitter facilitates the treatment of the user's tremor.
A method of generating jitter variation of nerve stimulation in a non-implantable wrist worn device to enhance therapeutic response for a user, the method comprising:
- measuring a pathological frequency of a user;
- calculating or setting a treatment frequency that is different from the pathological frequency to avoid exact alignment to the pathological frequency;
- and
- treating the user by stimulating at least two nerves, using at least two electrodes;
- wherein the at least two electrodes are located on the wrist-worn device,
- wherein the at least two electrodes are non-implantable,
- wherein the stimulating is performed using the treatment frequency,
- wherein the treatment frequency is jittered at a rate less than 100 Hz/s,
- wherein the treatment frequency comprises one or more of:
- (i) a burst frequency and a burst frequency variation and (ii) a pulse frequency and a pulse frequency variation,
- wherein if the treatment frequency comprises the burst frequency, the burst frequency is centered around the pathological frequency of the user and the burst frequency variation varies by less than 6 Hz from the measured pathological tremor frequency of the user,
- wherein if the treatment frequency comprises the pulse frequency, the pulse frequency is varied in a range of 50-150 Hz,
- wherein at least one of (i) the burst frequency is jittered at a rate between 0.01 Hz/s and 0.1 Hz/s or (ii) the pulse frequency is jittered at a rate between 1 Hz/s and 10 Hz/s, and
- wherein the jitter is therapeutically effective to reduce habituation to a therapy for the user.
Dependencies are inferred from the claim text.