Differential pressure fluid delivery system

A system for delivering a medicinal fluid to a patient comprising:

• a housing having a shape and size to receive and secure a detachable, pre-filled syringe, at least a portion of the syringe defining a medication chamber having a variable volume, the medication chamber configured to store medicinal fluid and having an outlet forming a fluid communication path to the patient;
• a pressure delivery chamber having a variable volume and configured to store pressure controllably, the pressure delivery chamber being fluidically isolated from the medication chamber;
• a movable delivery element disposed between the medication chamber and the pressure delivery chamber, the movable delivery element having a shape and size to fluidically isolate the medication chamber and the pressure delivery chamber;
• a pressure source coupled to the pressure delivery chamber, the pressure source comprising an elastomeric device that is pressurized with an impelling fluid, the impelling fluid being isolated from the medicinal fluid, the pressure source being configured to be utilized multiple times to selectively increase or decrease pressure within the pressure delivery chamber;
• a medication reservoir configured to be coupled to the medication chamber and configured to hold additional medicinal fluid;
• and
• a control sub-system configured to selectively send signals to cause pressure to be delivered from the pressure source to the pressure delivery chamber thereby causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber, the application of pressure to the medicinal fluid in the medication chamber causing the medicinal fluid to exit the medication chamber at the outlet along the fluid communication path to the patient, the control sub-system being further configured to automatically extract fluid from the medication reservoir and transfer the extracted fluid to the medication chamber.

A system for delivering a medicinal fluid to a patient comprising:

• means for securing a detachable, pre-filled syringe, at least a portion of the syringe defining a medication chamber having a variable volume, the medication chamber configured to store medicinal fluid and having an outlet forming a fluid communication path to the patient;
• a pressure delivery chamber having a variable volume and configured to store pressure controllably, the pressure delivery chamber being fluidically isolated from the medication chamber;
• a movable delivery element disposed between the medication chamber and the pressure delivery chamber, the movable delivery element having a shape and size to fluidically isolate the medication chamber and the pressure delivery chamber;
• a pressure source coupled to the pressure delivery chamber, the pressure source comprises a pneumatic pump configured to be utilized multiple times to selectively increase or decrease pressure within the pressure delivery chamber;
• a control sub-system configured to selectively send signals to cause pressure to be delivered from the pressure source to the pressure delivery chamber thereby causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber, the application of pressure to the medicinal fluid in the medication chamber causing the medicinal fluid to exit the medication chamber at the outlet along the fluid communication path to the patient;
• a medication reservoir configured to be coupled to the medication chamber and configured to hold additional medicinal fluid;
• and
• a handheld housing encapsulating each of the pressure delivery chamber, the movable delivery element, the pressure source, and the control sub-system;
• the handheld housing being configured such that when the medication chamber is at or below a level of medicinal fluid, pressure applied from the pressure delivery chamber causes a suction effect when an opening between the medication reservoir and the medication chamber is open thereby drawing medicinal fluid from the medication reservoir into the medication chamber.

A system for delivering a medicinal fluid to a patient comprising:

• a housing having a shape and size to be handheld and to receive and secure a detachable, pre-filled syringe without a plunger, the housing comprising a hinged lid to secure the pre-filled syringe, at least a portion of the syringe defining a medication chamber having a variable volume, the medication chamber configured to store medicinal fluid and having an outlet forming a fluid communication path to the patient;
• a pressure delivery chamber having a variable volume and configured to store pressure controllably, the pressure delivery chamber being fluidically isolated from the medication chamber;
• a movable delivery element within the housing and disposed between the medication chamber and the pressure delivery chamber, the movable delivery element having a shape and size to fluidically isolate the medication chamber and the pressure delivery chamber;
• a pressure source self-contained within the housing and which is coupled to the pressure delivery chamber, the pressure source comprising an electromechanical air pump that is configured to be utilized multiple times to selectively increase or decrease pressure within the pressure delivery chamber;
• a medication reservoir configured to be coupled to the medication chamber and configured to hold additional medicinal fluid;
• a control sub-system configured to selectively send signals to cause pressure to be delivered from the pressure source to the pressure delivery chamber thereby causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber, the application of pressure to the medicinal fluid in the medication chamber causing the medicinal fluid to exit the medication chamber at the outlet along the fluid communication path to the patient;
• a wireless communications interface configured to bi-directionally exchange data over a communications network with a remote computing device associated with delivery of the medicinal fluid including instructions to the control sub-system;
• and
• the housing encapsulating each of the pressure delivery chamber, the movable delivery element, the pressure source, the medication reservoir, the control sub-system, and the wireless communications interface.

A handheld system for delivering a medicinal fluid to a patient, comprising:

• a housing sized and shaped to be held in one hand of a user while at least one input element is activated by another hand of the user, the housing comprising a hinged lid configured to open to receive a detachable, pre-filled syringe without an integral plunger and close to secure the detachable, pre-filled syringe, at least a portion of the syringe defining a medication chamber having a variable volume, the medication chamber configured to store medicinal fluid and having an outlet forming a fluid communication path to the patient;
• a pressure delivery chamber having a variable volume and configured to store pressure controllably, the pressure delivery chamber being fluidically isolated from the medication chamber;
• a movable delivery element within the housing and disposed between the medication chamber and the pressure delivery chamber, the movable delivery element comprising an elastomeric membrane or a bellows element with collapsible sides, the movable delivery element having a shape and a size to fluidically isolate the medication chamber and the pressure delivery chamber;
• a pressure source self-contained within the housing and coupled to the pressure delivery chamber, the pressure source comprising a piezoelectric air pump configured to be utilized multiple times to selectively increase or decrease pressure within the pressure delivery chamber;
• a valve manifold disposed between the pressure source and the pressure delivery chamber for selectively delivering pressure from the pressure source to the pressure delivery chamber at a controlled rate;
• a pressure delivery chamber pressure sensor coupled to or adjacent to the pressure delivery chamber and configured to generate a first pressure value characterizing a level of pressure within the pressure delivery chamber;
• a reference pressure chamber having a fixed volume and a reference pressure chamber pressure sensor coupled to or adjacent to the reference pressure chamber, the reference pressure chamber pressure sensor configured to generate a second pressure value characterizing a level of pressure within the reference pressure chamber;
• a medication reservoir configured to be coupled to the medication chamber and configured to hold additional medicinal fluid;
• a control sub-system configured to send signals to the piezoelectric air pump and the valve manifold to selectively cause pressure to be delivered from the pressure source to the pressure delivery chamber at the controlled rate, thereby causing the movable delivery element to deform and apply pressure to the medicinal fluid in the medication chamber, the application of pressure to the medicinal fluid causing the medicinal fluid to exit the medication chamber at the outlet along the fluid communication path to the patient, the control sub-system being configured to calculate an amount of medicinal fluid within the medication chamber based on a differential pressure measurement using the first pressure value and the second pressure value, and the control sub-system being further configured to calculate occlusions within the fluid communication path using the first pressure value and the second pressure value, the control sub-system being further configured to automatically extract fluid from the medication reservoir and transfer the extracted fluid to the medication chamber;
• a user interface comprising an electronic display and at least one input element configured to alter a parameter associated with delivery of the medicinal fluid to the patient;
• and
• a wireless communications interface configured to bi-directionally exchange data over a communications network with a remote computing device associated with delivery of the medicinal fluid including instructions to the control sub-system;
• the housing at least partially encapsulating each of the pressure delivery chamber, the movable delivery element, the pressure source, the valve manifold, the pressure delivery chamber pressure sensor, the reference pressure chamber, the reference pressure chamber pressure sensor, the medication reservoir, the control sub-system, and the wireless communications interface, the housing partially encapsulating the user interface such that the user interface remains accessible to the user.