Drug delivery device actuated using lead screw and motor

A system comprising a medical device, the medical device comprising:

• at least one drug chamber that comprises a drug;
• a motor chamber that comprises a housing, a motor, and a component that drives a piston that is affixed to a first end of the component;
• an electronic component that actuates the motor to operate the component and move the piston longitudinally to discharge the drug outside the medical device through one or more orifices;
• a semipermeable membrane that allows passive ingress flow of a liquid from a liquid environment outside the medical device to inside of the medical device, thereby generating osmotic pressure to drive the piston longitudinally towards the one or more orifices in addition to actuation of the piston by the motor;
• wherein the motor chamber is configured to pressurize a gas within the motor chamber such that pressurization of the gas restricts creation of vacuum within the medical device when the piston moves longitudinally toward the one or more orifices;
• and wherein the medical device is configured to be or not be implanted in a body of a mammal.