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AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph T. Delaney, Jr., Kolbein Kolste, Tatyana Dyndikova, Yen-Hao Hsu
Estimating the term…
In some embodiments, the present disclosure pertains to systems for forming a hydrogel that comprise (a) a first composition that comprises a polyiodinated polyamino compound and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to medical hydrogels that are formed by reacting a polyiodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to methods of making polyiodinated polyamino compounds.
A system for forming a hydrogel that comprises (a) a first composition that comprises a polyiodinated polyamino compound comprising (i) a polyamino moiety comprising a plurality of amino groups and (ii) a plurality of iodinated aromatic moieties and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the polyiodinated polyamino compound, wherein the polyamino moiety is a residue of a lysine oligomer or a residue of a carboxy terminated polyamine, wherein the polyiodinated polyamino compound comprises a core, wherein the polyamino moiety is linked to the core by an amide group, and wherein the iodinated aromatic moieties are each linked to the core by an amide group.
Dependencies are inferred from the claim text.