Ionizable cationic lipid analog material and use thereof as drug delivery carrier
AssigneeGuangzhou Lide Biomedicine Technology Co., Ltd.
InventorsZhijia Liu, Zhicheng Le, Zepeng He, Yongming Chen
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Abstract
The present disclosure discloses an ionizable cationic lipid analog material and use thereof as a drug delivery carrier. In the present disclosure, a series of cationic lipid analog materials are reasonably designed, and a preparation method of the cationic lipid analog materials involves mild reaction conditions, a simple process, and excellent stability. The cationic lipid analog materials have excellent biocompatibility, and can allow an efficient and safe intracellular delivery of a biomacromolecular drug. The cationic lipid analog materials can also be used as delivery carriers for other types of drugs.
Claims20
An ionizable cationic lipid analog material with a structure shown in formula (I):
- wherein m1 is independently selected from the group consisting of a linear alkyl, a branched alkyl, phenyl, and a heteroatom-containing aryl;
- m2 is
- R1 is an alkyl, R2 is an alkyl, R3 is an alkyl or phenyl, or R2 and R3 are connected as a cyclic group or a heterocyclic group;
- m3 is independently selected from the group consisting of a linear alkyl, a linear alkenyl, and
- and
- m4 is independently selected from the group consisting of a linear alkyl, an ether bond-containing linear alkyl, and a N-heterocycle-containing alkyl.
Dependencies are inferred from the claim text.