Methods for increasing the bioavailability of nucleoside medicinal agents
AssigneeUcb Biosciences, Inc.
InventorAravind Mittur
Life of this patent
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Abstract
Provided are methods for increasing the bioavailability of nucleoside medicinal agents in treating mitochondrial depletion syndromes. In particular, the methods relate to increasing the bioavailability of deoxycytidine and deoxythymidine by administering a therapeutically effective amount of deoxycytidine and deoxythymidine with food.
Claims23
A method of increasing the oral bioavailability of deoxycytidine (dC) and deoxythymidine (dT) to a patient receiving therapy for a mitochondrial depletion syndrome (MDS) comprising administering to the patient in need thereof, or instructing a patient caregiver to administer, a therapeutically effective amount of dC and dT with food, wherein the dC and dT is administered at the same time as or up to about 30 minutes after oral administration of food, and wherein the food is a high fat, high calorie meal.
A method of increasing the amount of deoxycytidine (dC) absorbed by a patient's body comprising administering a dose with a combined weight of dC and deoxythymidine (dT) of between about 100 mg/kg and about 200 mg/kg containing equal parts of dC and dT, wherein the administering is with food, wherein the dC and dT is administered at the same time as or up to about 30 minutes after oral administration of food, and wherein the food is a high fat, high calorie meal.
A method of treating a mitochondrial depletion syndrome patient comprising, administering to the patient a therapeutically effective amount of deoxycytidine (dC) and a therapeutically effective amount of deoxythymidine (dT) and directing the patient to take the dC and dT with food, wherein the dC and dT is administered at the same time as or up to about 30 minutes after oral administration of food, and wherein the food is a high fat, high calorie meal.
Dependencies are inferred from the claim text.