Tetracycline derivatives for treating neurodegenerative or neuroinflammatory diseases
AssigneeInstitut Du Cerveau Et De La Moelle Epiniere
InventorsBruno Figadere, Rita Raisman-Vozari, Patrick Pierre Michel, Laurent Ferrie, Clémence Rose
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Abstract
The present invention relates to the field of medicine. In particular, it relates to the use of tetracycline derivatives in the treatment or prevention of a neurodegenerative or neuroinflammatory disease, such as Parkinson's disease.
Claims14
A method of treating a neurodegenerative or neuroinflammatory disease comprising administering a compound represented by the following formula (I):
- wherein R is a hydrogen atom or a methyl group, or a pharmaceutically acceptable salt or solvate thereof, to a subject in need of treatment.
A pharmaceutical composition comprising a compound of formula (I-H):
- or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable excipient.
A process for preparing a compound of formula (I):
- wherein R is a hydrogen atom or a methyl group, said process comprising the steps of:
- (a) contacting a compound of formula (III) with an acid H+, X− wherein X− is an anion,
- wherein R is a hydrogen atom or a methyl group, so as to obtain a compound of formula (II):
- wherein R is a hydrogen atom or a methyl group,
- R′ is a hydrogen atom, and
- X− is an anion;
- (b) reacting said compound of formula (II) with a reducing system.
A process for preparing a compound of formula (I):
- wherein R is a hydrogen atom or a methyl group, said process comprising the step of:
- (a) reacting a compound of formula (II) with a reducing system:
- wherein R is a hydrogen atom or a methyl group,
- R′ is a methyl group, and
- X− is an anion.
Dependencies are inferred from the claim text.