LOX enzyme inhibiting methods and compositions

A LOX enzyme-inhibiting compound in accordance with Formula I, or a pharmaceutically acceptable salt or hydrate thereof:

• wherein:
• T, U, and V are nitrogen or carbon and only one of T, U, and Vis nitrogen;
• X is independently selected from —OR1, —SO2R1, and —C(═O)R1;
• Y is independently selected from —OR2, —SO2R2, and —C(═O)R2;
• Z is independently selected from —R3, —CH2—R3, —SO2R3, —C(═O)R3, and —OR3;
• R1 is phenyl or heteroaryl containing 1 to 2 heteroatom(s) each independently selected from N, O, and S,
• wherein said phenyl or heteroaryl is substituted with —CR4R5NH2 and optionally substituted with halogen or lower alkyl, and
• wherein R4 and R5 are independently H or lower alkyl or R4 and R5 form a (C3-C8) cycloalkyl or (C1-C8) hetero-cycloalkyl or R4 and R5 are both H;
• R2 is substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substituted or unsubstituted heteroaryl containing 1 to 2 heteroatom(s) each independently selected from N, O, and S, (C1-C8) alkyl, (C3-C8) cycloalkyl, mono-, di-, or trihalo(C1-C4)alkyl, or —NR6R7,
• wherein R6 and R7 are independently selected from H and lower alkyl or R6 and R7 form together a (C3-C6) hetero-cycloalkyl,
• wherein the (C3-C6) hetero-cycloalkyl optionally contains one additional heteroatom selected from N, O, and S,
• wherein N is optionally substituted with lower alkyl, —SO2R8, or —OR8,
• wherein S is unsubstituted or forms sulfonyl,
• wherein said substituted phenyl, substituted benzyl, or substituted heteroaryl has at least one substituent being halogen, mono-, di-, or tri-halo(C1-C4)alkyl, —SO2R8, or —OR8,
• wherein R8 is lower alkyl, cyano, lower alkyl, or —SO2NR9R10, and
• wherein R9 and R10 are independently selected from H and lower alkyl;
• R3 is unsubstituted or substituted phenyl, substituted or unsubstituted benzyl, substituted or unsubstituted heteroaryl containing 1 to 2 heteroatom(s) each independently selected from N, O, and S, mono-, di-, or tri-halo(C1-C4)alkyl, (C3-C8) cycloalkyl, (C1-C8) alkyl, or —NR11R12,
• wherein R11 and R12 are independently selected from H and lower alkyl or R11 and R12 form together a (C3-C6) hetero-cycloalkyl,
• wherein the (C3-C6) hetero-cycloalkyl optionally contains one additional heteroatom selected from N, O, and S,
• wherein N is optionally substituted with lower alkyl, —SO2R13, or —OR13,
• wherein S is unsubstituted or forms sulfonyl,
• wherein said substituted phenyl, substituted benzyl, or substituted heteroaryl has at least one substituent being halogen, mono-, di- or tri-halo(C1-C4)alkyl, —SO2R14, or —OR14,
• wherein R14 is lower alkyl, cyano, lower alkyl, or —SO2NR15R16, and
• wherein R15 and R16 are independently selected from H and lower alkyl;
• or a tautomer or stereoisomer thereof.