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US 12,746,242 B2Granted
Combination therapies of FASN inhibitors with thyroid hormone receptor agonists
AssigneeSagimet Biosciences Inc.
InventorsAnne-Marie O'Farrell, George Kemble, Wen-Wei Tsai
Life of this patent
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Abstract
Therapeutic combinations of fatty acid synthesis modulators and thyroid hormone receptor agonists are provided. The combinations may be used to treat disorders including metabolic disorders and liver disorders, such as nonalcoholic steatohepatitis/metabolic dysfunction-associated steatohepatitis (NASH/MASH).
Claims18
A pharmaceutical composition comprising a therapeutically effective amount of:
- a fatty acid synthase (FASN) inhibitor of formula:
- or a pharmaceutically acceptable salt thereof, and;
- a thyroid hormone receptor-beta (THR-B) agonist of formula:
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.