Compositions and methods comprising endothelin a receptor antagonists and androgen therapies

Abstract

Disclosed are compositions comprising an endothelin A receptor (ETAR) antagonist, an anti-androgen therapy, and chemical castration therapy. Also disclosed are compositions comprising an ETAR antagonist, copackaged or coformulated with an anti-androgen therapy. Disclosed are methods of preventing prostate cancer metastasis comprising administering to a subject having prostate cancer an ETAR antagonist, an anti-androgen therapy, and castration therapy. Also disclosed are methods of increasing survival in a prostate cancer patient, comprising administering to the patient having prostate cancer an ETAR antagonist, an anti-androgen therapy, and castration therapy.

Dependencies are inferred from the claim text.