Use of dextromethorphan in combination with CYP2D6 and CYP3A4 enzyme inhibitors for the treatment of pain
AssigneeBiobina LLC
InventorRobert Taub
Life of this patent
Estimating the term…
Abstract
Methods and compositions for treating pain are provided. Methods for treating pain include administering an effective amount of dextromethorphan or a pharmaceutically acceptable salt thereof in combination with a CYP2D6 enzyme inhibitor and a CYP3A4 enzyme inhibitor to a subject in need thereof. Compositions for treating pain that include dextromethorphan or a pharmaceutically acceptable salt thereof in combination with a CYP2D6 enzyme inhibitor and a CYP3A4 enzyme inhibitor are administered to a subject in need thereof.
Claims25
A method for treatment of pain comprising administering to a patient in need thereof dextromethorphan or a pharmaceutically acceptable salt thereof in combination with a CYP2D6 inhibitor and methocarbamol, wherein the CYP2D6 inhibitor is selected from the group consisting of quinidine, quinine, ajmaline, amiodarone, cannabidiol, celecoxib, chlorphenamine, chlorpromazine, cimetidine, cinacalcet, citalopram, clemastine, clomipramine, cocaine, diphenhydramine, doxepin, doxorubicin, duloxetine, escitalopram, fluoxetine, halofantrine, haloperidol, hydroxyzine, hyperforinkava, levomepromazine, lobeline, methadone, methylphenidate, metoclopramide, mibefradil, midodrine, niacin, niacinamide, Nelumbo nucifera, nuciferine, n-nornuciferine, 2-hydroxy-1-methoxyaporphine, omeprazole, paroxetine, perphenazine, promethazine, ranitidine, risperidone, ritonavir, sertraline, St. John's Wort, terbinafine, thioridazine, ticlopidine, tripelennamine, yohimbine and zuclopenthixol.
A pharmaceutical composition comprising dextromethorphan or a pharmaceutically acceptable salt thereof, a CYP2D6 inhibitor and methocarbamol, wherein the CYP2D6 inhibitor is selected from the group consisting of quinidine, quinine, ajmaline, amiodarone, cannabidiol, celecoxib, chlorphenamine, chlorpromazine, cimetidine, cinacalcet, citalopram, clemastine, clomipramine, cocaine, diphenhydramine, doxepin, doxorubicin, duloxetine, escitalopram, fluoxetine, halofantrine, haloperidol, hydroxyzine, hyperforinkava, levomepromazine, lobeline, methadone, methylphenidate, metoclopramide, mibefradil, midodrine, niacin, niacinamide, Nelumbo nucifera, nuciferine, n-nornuciferine, 2-hydroxy-1-methoxyaporphine, omeprazole, paroxetine, perphenazine, promethazine, ranitidine, risperidone, ritonavir, sertraline, St. John's Wort, terbinafine, thioridazine, ticlopidine, tripelennamine, yohimbine and zuclopenthixol.
Dependencies are inferred from the claim text.