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AssigneeArivin Therapeutics Oy
InventorsChristopher Jonkergouw, Ekaterina Osmekhina, Markus Linder, Katarzyna Leskinen, Päivi Saavalainen
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This invention relates to use of a macrocyclic cavity-containing compound sensitizing a microbe towards an antimicrobial agent. The invention also relates to use of a macrocyclic cavity-containing compound in reducing the amount of an antimicrobial agent needed to prevent or inhibit the growth of a microbe in a subject. Further, the invention relates to use of a macrocyclic cavity-containing compound in reducing the build-up of resistance of a microbe towards an anti-microbial agent. The invention also relates to a macrocyclic cavity-containing compound and an antimicrobial agent for use in inhibiting/treating/preventing a microbial infection in a subject having a microbial infection or being at risk of a microbial infection.
A method of sensitizing a gram-negative bacterium or reducing build-up of resistance of a gram-negative bacterium towards an antimicrobial agent by exposing the microbe to a pillararene and the antimicrobial agent.
A method of inhibiting and/or treating and/or preventing a microbial infection in a subject having a microbial infection or being at risk of a microbial infection or formation of a biofilm by a gram-negative bacterium in the subject by administering an antimicrobial agent and a pillararene to the subject.
Dependencies are inferred from the claim text.