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US 12,746,201 B2Granted
Nanomaterials
AssigneeGuide Therapeutics, LLC
InventorsNeeraj Narendra Patwardhan, Milloni Balwantkumar Chhabra, Gregory Lawrence Hamilton, Cory Dane Sago, Mina Fawzy Gaballa Shehata
Life of this patent
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Abstract
Lipid nanoparticle compositions for delivery of nucleic acids are described. The lipid nanoparticle may contain a conformationally constrained ionizable lipid as part of the composition. These compositions may allow for delivery of cargo without the need for a targeting ligand.
Claims20
A compound of Formula (IIb):
- wherein:
- R9 is C9-C20 alkyl optionally fused with 1-4 C3-C6 cycloalkyl groups, C9-C20 alkenyl with 1-3 units of unsaturation, or —(CH2)g—X17, wherein X17 is optionally substituted C4-C12 cycloalkyl;
- f is independently an integer from 0-6;
- R16 is hydrogen or optionally substituted C5-C6 aryl;
- X15 is optionally substituted C4-C12 cycloalkyl or optionally substituted C5-C10 aryl;
- and
- X16 is hydrogen or optionally substituted C4-C12 cycloalkyl;
- provided that when f is 1 and R9 is
- X15 is not
6 more elements
Dependencies are inferred from the claim text.