Trans-septal delivery system and methods of use

A method of delivering and deploying a heart valve prosthesis, the method comprising:

• positioning a delivery catheter at a site of a native heart valve with the heart valve prosthesis in a radially compressed configuration within the delivery catheter, wherein the heart valve prosthesis includes an outer member coupled to an inner member and a prosthetic valve coupled to the inner member, wherein the delivery catheter includes an outer shaft, an intermediate shaft, an inner shaft, and a distal tip component coupled to a distal portion of the inner shaft, the distal tip component including a distal shaft component extending proximally from the distal tip component, wherein in the delivery configuration the distal shaft component encircles an outflow portion of the heart valve prosthesis;
• retracting the outer shaft to release the outer member of the heart valve prosthesis from the outer shaft such that the outer member radially expands;
• retracting the intermediate shaft to release the inner member of the heart valve prosthesis from the intermediate shaft such that the inner member radially expands;
• and
• advancing the inner shaft to distally advance the distal shaft component to release the outflow portion of the heart valve prosthesis from the distal shaft component such that the outflow portion of the heart valve prosthesis radially expands.