Donor overlay for treatment or alleviation of anterior corneal disorders
AssigneeNiios-USA Inc.
InventorGerrit Reinold Jacob Melles
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Abstract
The invention relates to methods for the treatment or alleviation of an anterior corneal disorder in a subject in need thereof comprising removing corneal epithelial cells from an eye of said subject without removing any corneal tissue or other ocular tissue located posterior to the corneal epithelial cell layer; and positioning an overlay comprising a Bowman layer (BL), Descemet membrane (DM) and/or crystalline lens capsule on the anterior surface of said corneal tissue located posterior to the corneal epithelial cell layer. The invention further relates to freeze-dried and/or gamma irradiated Bowman layer, Descemet membrane and/or crystalline lens capsule and compositions comprising the same that are useful in such methods.
Claims19
A method for the treatment or alleviation of an anterior corneal disorder in a subject in need thereof, the method comprising:
- removing corneal epithelial cells from an eye of said subject without removing any corneal tissue or other ocular tissue located posterior to the corneal epithelial cell layer;
- and
- positioning an overlay consisting of a Bowman layer (BL) or consisting of more than one BL, on the anterior surface of said corneal tissue located posterior to the corneal epithelial cell layer.
Dependencies are inferred from the claim text.