Systems and methods for personalized medicine in IVF for reduced dosage and testing, and better outcomes

A method for facilitating an optimized and personalized drug treatment for in vitro fertilization (IVF) patients comprising the steps of:

• providing an ultrasound apparatus configured to identify and measure follicle sizes in an IVF patient;
• obtaining first follicle size distribution data of the IVF patient using the apparatus at a first time;
• determining an initial hormone dosage for administering to the IVF patient;
• administering the initial hormone dosage to the IVF patient until a second time;
• obtaining second follicle size distribution data of the IVF patient using the ultrasound apparatus configured to identify and measure follicle sizes in the IVF patient at the second time;
• providing a decision support tool comprising a software application configured to operate on a computing device, wherein the decision support tool is configured to calculate an optimized drug treatment plan for the IVF patient;
• entering the first follicle size distribution data of the IVF patient, second follicle size distribution data of the IVF patient, and the initial hormone dosage administered to the IVF patient at the first time;
• calculating the optimal daily hormone dosage for the IVF patient using the decision support tool, wherein the decision support tool uses optimal control theory comprising differential-algebraic equations using the first and the second follicle size distribution data of the patient and information about the initial hormone dosage;
• and
• administering the optimal daily hormone dosage to the IVF patient for a cycle of IVF treatment.