Method, system and device for individualized supplemental oxygen therapy for preterm infants

A method for dynamically targeting oxygen saturation for preterm infants, comprising:

• monitoring, via a monitoring device, heart rate in a preterm infant;
• determining, via a computing device, a pulmonary resilience measurement in the preterm infant, wherein the pulmonary resilience measurement is based on a heart rate variability measurement determined based on the monitored heart rate;
• and
• adjusting an oxygen saturation target range for the preterm infant, wherein the oxygen saturation target range is adjusted according to a coefficient multiplied by the heart rate variability measurement.

A system comprising:

• a computing device comprising a processor and a memory storing instructions which, when executed by the processor, cause the processor to:
• determine a heart rate variability measurement in the preterm infant based on a monitored heart rate;
• determine an oxygen saturation target range for the preterm infant;
• adjust the oxygen saturation target range according to a coefficient multiplied by the heart rate variability measurement;
• and
• issue an alert conveying the oxygen saturation target range for the preterm infant.

A method for dynamically targeting oxygen saturation for preterm infants, comprising:

• monitoring, via a monitoring device, heart rate in a preterm infant to determine a heart rate variability measurement;
• and
• adjusting an oxygen saturation target range for the preterm infant, wherein adjusting the oxygen saturation target range is based on the heart rate variability measurement;
• determining a probability of one or more outcomes based on the heart rate variability measurement at a continuum of oxygen saturation target ranges;
• summing the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• and
• selecting the oxygen saturation target range that has the lowest cost or the highest utility.

A method for dynamically targeting oxygen saturation for preterm infants, comprising:

• monitoring, via a monitoring device, heart rate in a preterm infant to determine a heart rate variability measurement;
• adjusting an oxygen saturation target range for the preterm infant, wherein adjusting the oxygen saturation target range is based on the heart rate variability measurement;
• and
• determining if the heart rate variability measurement meets or exceeds a pre-established threshold, wherein the pre-established threshold is determined by:
• determining a probability of one or more outcomes based on the heart rate variability measurement at both a low and a high oxygen saturation target range;
• summing the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• and
• selecting the oxygen saturation target range that has a lower cost or a higher utility.

A method for dynamically targeting oxygen saturation for preterm infants, comprising:

• monitoring, via a monitoring device, heart rate in a preterm infant;
• determining, via a computing device, a pulmonary resilience measurement in the preterm infant, wherein the pulmonary resilience measurement is based on a heart rate variability measurement determined based on the monitored heart rate;
• adjusting an oxygen saturation target range for the preterm infant, wherein adjusting the oxygen saturation target range is based on the pulmonary resilience measurement,
• determining a probability of one or more outcomes based on the pulmonary resilience measurement at a continuum of oxygen saturation target ranges;
• summing the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• and
• selecting the oxygen saturation target range that has the lowest cost or the highest utility.

A method for dynamically targeting oxygen saturation for preterm infants, comprising:

• monitoring, via a monitoring device, heart rate in a preterm infant;
• determining, via a computing device, a pulmonary resilience measurement in the preterm infant, wherein the pulmonary resilience measurement is based on a heart rate variability measurement determined based on the monitored heart rate;
• adjusting an oxygen saturation target range for the preterm infant, wherein adjusting the oxygen saturation target range is based on the pulmonary resilience measurement;
• and
• determining if the pulmonary resilience measurement meets or exceeds a pre-established threshold, wherein the pre-established threshold is determined by:
• determining a probability of one or more outcomes based on the pulmonary resilience measurement at both a low and a high oxygen saturation target range;
• summing the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• and
• selecting the oxygen saturation target range that has a lower cost or a higher utility.

A system comprising:

• a computing device comprising a processor and a memory storing instructions which, when executed by the processor, cause the processor to:
• determine a heart rate variability measurement in the preterm infant based on a monitored heart rate;
• determine a probability of one or more outcomes based on the heart rate variability measurement at a continuum of oxygen saturation target ranges;
• sum the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• select an oxygen saturation target range that has the lowest cost or the highest utility;
• and
• issue an alert conveying the oxygen saturation target range for the preterm infant.

A system comprising:

• a computing device comprising a processor and a memory storing instructions which, when executed by the processor, cause the processor to:
• determine a heart rate variability measurement in the preterm infant based on a monitored heart rate;
• determine if the heart rate variability measurement meets or exceeds a pre-established threshold, wherein the pre-established threshold is determined by:
• determining a probability of one or more outcomes based on the heart rate variability measurement at both a low and a high oxygen saturation target range;
• summing the product of a cost or a utility associated with each of the one or more outcomes, where each cost or each utility is weighted by the determined probability;
• and
• selecting an oxygen saturation target range that has a lower cost or a higher utility;
• and
• issue an alert conveying the oxygen saturation target range for the preterm infant.