Use of E. coli strains expressing high level of α-Gal to modulate immunity and provide protection against infectious diseases in animals

A method for preventing and/or reducing, in a non-human animal that does not produce α-Gal, an infectious disease caused by a pathogen expressing α-Gal on its surface, comprising administering to the non-human animal an E. coli strain, wherein the E. coli is E. coli Nissle 1917, the non-human animal is fish, and the pathogen expressing α-Gal on its surface is a myxozoan parasite.

A method for preventing and/or reducing, in a non-human animal that does not produce α-Gal, an infectious disease caused by a pathogen expressing α-Gal on its surface, comprising administering to the non-human animal an E. coli strain, wherein the E. coli is E. coli O86:B7, the non-human animal is poultry, and the pathogen expressing α-Gal on its surface is an Aspergillus.