Systems, devices and methods for neurofeedback to promote brain coherence

A method for providing neurofeedback, comprising:

• presenting, at a display device, stimuli to a subject to invoke generation of neurological signal stimulation in a brain of a subject;
• measuring, at a brain signal detection device, a plurality of sets of brain signal data that include at least two individual brain signals from the subject's brain acquired during a neurofeedback session having a plurality of neurofeedback periods without acquiring the at least two individual brain signals during one or more break periods arranged between adjacent neurofeedback periods, wherein each of the at least two individual brain signals correspond to at least two locations on the subject's brain including a first location on the subject's left-side frontal lobe and a second location on the subject's right-side frontal lobe;
• and
• analyzing, at a data processing device in real time during the neurofeedback session, the brain signal data to determine a coherence value for a neurofeedback period of the plurality of neurofeedback periods based on a dynamic threshold, wherein the dynamic threshold is determined based at least on the coherence value from a prior neurofeedback period,
• wherein the dynamic threshold is determined by calculating an amount of overlap of the at least two individual brain signals in the neurofeedback period with respect to time and producing a threshold value corresponding to a percentile of the amount of overlap,
• wherein the percentile is in a range of 15% to 30%.

A method for providing neurofeedback, comprising:

• presenting, at a display device, stimuli to a subject to invoke generation of neurological signal stimulation in a brain of a subject;
• measuring, at a brain signal detection device, a plurality of sets of brain signal data that include at least two individual brain signals from the subject's brain acquired during a neurofeedback session having a plurality of neurofeedback periods without acquiring the at least two individual brain signals during one or more break periods arranged between adjacent neurofeedback periods, wherein each of the at least two individual brain signals correspond to at least two locations on the subject's brain including a first location on the subject's left-side frontal lobe and a second location on the subject's right-side frontal lobe;
• analyzing, at a data processing device in real time during the neurofeedback session, the brain signal data to determine a coherence value for a neurofeedback period of the plurality of neurofeedback periods based on a dynamic threshold, wherein the dynamic threshold is determined based at least on the coherence value from a prior neurofeedback period;
• determining an optimal work-to-rest ratio based at least on the dynamic threshold;
• and
• extending a duration of a break period of the one or more break periods arranged between adjacent neurofeedback periods based on a decrease in a value or series of values of the dynamic threshold;
• or
• reducing a duration of a break period of the one or more break periods arranged between adjacent neurofeedback periods based on an increase in a value or series of values of the dynamic threshold.

A method for providing neurofeedback, comprising:

• presenting, at a display device, stimuli to a subject to invoke generation of neurological signal stimulation in a brain of a subject;
• measuring, at a brain signal detection device, a plurality of sets of brain signal data that include at least two individual brain signals from the subject's brain acquired during a neurofeedback session having a plurality of neurofeedback periods without acquiring the at least two individual brain signals during one or more break periods arranged between adjacent neurofeedback periods, wherein each of the at least two individual brain signals correspond to at least two locations on the subject's brain including a first location on the subject's left-side frontal lobe and a second location on the subject's right-side frontal lobe;
• and
• analyzing, at a data processing device in real time during the neurofeedback session, the brain signal data to determine a coherence value for a neurofeedback period of the plurality of neurofeedback periods based on a dynamic threshold, wherein the dynamic threshold is determined based at least on the coherence value from a prior neurofeedback period,
• wherein the analyzing the brain signal data to determine the coherence value for a neurofeedback period based on the dynamic threshold comprises:
• receiving a preliminary set of brain signal data acquired over a preliminary time interval;
• and
• analyzing the preliminary set of brain signal data to determine a baseline threshold by calculating an amount of overlap of the at least two individual brain signals with respect to time during the preliminary time interval and producing the baseline threshold to be a value corresponding to a percentile in a range of 15% to 30% of the amount of overlap.

A method for providing neurofeedback, comprising:

• presenting, at a display device, stimuli to a subject to invoke generation of neurological signal stimulation in a brain of a subject;
• measuring, at a brain signal detection device, a plurality of sets of brain signal data that include at least two individual brain signals from the subject's brain acquired during a neurofeedback session having a plurality of neurofeedback periods without acquiring the at least two individual brain signals during one or more break periods arranged between adjacent neurofeedback periods, wherein each of the at least two individual brain signals correspond to at least two locations on the subject's brain including a first location on the subject's left-side frontal lobe and a second location on the subject's right-side frontal lobe;
• analyzing, at a data processing device in real time during the neurofeedback session, the brain signal data to determine a coherence value for a neurofeedback period of the plurality of neurofeedback periods based on a dynamic threshold, wherein the dynamic threshold is determined based at least on the coherence value from a prior neurofeedback period;
• and
• controlling, at the data processing device, the presentation of the stimuli, by the display device, during the plurality of neurofeedback periods based on the coherence value, wherein, when the coherence value is determined to not satisfy the dynamic threshold, the stimuli is adjusted by at least temporarily discontinuing the presentation and/or altering content of the presentation, and/or wherein when the coherence value is determined to satisfy the dynamic threshold, the stimuli is adjusted by at least temporarily continuing the presentation and/or altering the content of the presentation.

A non-transitory, computer-readable medium storing instructions thereon that, when executed by one or more processors of a computing system, cause the computing system to perform operations for analyzing and utilizing neurofeedback from brain signal data of a subject in real time, the brain signal data including at least two individual brain signals from the subject's brain acquired from two or more electrodes during a neurofeedback session having a plurality of neurofeedback periods without acquiring the at least two individual brain signals during one or more break periods arranged between adjacent neurofeedback periods, wherein each of the at least two individual brain signals correspond to at least two locations on the subject's brain including a first location on the subject's left-side frontal lobe where a first electrode is positioned and a second location on the subject's right-side frontal lobe where a second electrode is positioned, the operations comprising:

• receiving a first set of the brain signal data over a first time interval of a first neurofeedback period that follows a preliminary time interval, wherein the first time interval and the preliminary time interval are different time intervals;
• analyzing the first set of brain signal data by calculating an amount of overlap of the at least two individual brain signals with respect to time during the first time interval;
• and
• producing a first dynamic threshold to be a value corresponding to a percentile of the amount of overlap when a baseline threshold was satisfied by the first set of brain signal data of the first time interval, or
• maintaining a baseline threshold for a subsequent time interval when the baseline threshold was not satisfied by the first set of brain signal data, wherein the subsequent time interval and the first time interval are different time intervals.