Assay and kit for live antigen detection and monitoring of neurocysticercosis

Abstract

The present invention broadly relates to the field of proteomics, bioinformatics & immunology for detection of Neurocysticercosis (NCC). More specifically, the present invention relates to an in vitro immunoassay for the diagnosis of active neurocysticercosis in biological samples. Further, the present invention relates to the identification of a novel antigen comprising of 219 amino acids of Putative lysine rich protein (PLRP) 25 kDa and its use in the detection of Neurocysticercosis. The amino acid sequences of antigenic polypeptides TSPP21 and TSPP22 are provided, polypeptides are useful as detection tool for identification of T. solium for recognizing active antigens in biological samples. In broad spectrum the invention defined here provides method for detecting active antigen in serum and urine of neurocysticercosis patients in kit formulation. In solitary cyst cases and cases where diagnosis is not clear by neuroimaging, this test will be helpful.

Dependencies are inferred from the claim text.