Method of evaluating function of organ for transplantation, program for evaluating function of organ for transplantation, and apparatus that evaluates function of organ for transplantation

A method of transplanting of a liver for transplantation harvested from a living body for treatment of liver failure, the method comprising:

• measuring contents of marker substances in a first tissue sample that is taken from the liver for transplantation at a first timing in a reperfusion of the liver for transplantation;
• measuring contents of the marker substances in a second tissue sample that is taken from the liver for transplantation at a second timing after the first timing in the reperfusion;
• calculating a change including an increase or a decrease in content at the second timing as compared with the first timing for each of the marker substances;
• calculating an indicator relating to evaluation of the function of the liver for transplantation using the calculated change in content and data representing change over time in contents of the marker substances in accordance with a perfusion,
• wherein the marker substances include at least two of sedoheptulose 7-phosphate, adenosine triphosphate, glucose-6-phosphate, succinyl coenzyme A (CoA), dimethylglycine, choline, 2-aminobutyric acid, uric acid, pyruvic acid, and inosine,
• wherein the calculating change includes calculating a tendency of change in the content, and the calculating an indicator includes expressing the tendency of change in the content for each marker substance measured as a numerical score, the expressing the tendency as the numerical score includes setting a score at a time when the tendency of change in the content in the liver for transplantation agrees with the tendency of change in the content in a liver having normal function to be larger than a score at a time when the tendency of change in the content in the liver for transplantation does not agree with the tendency of change in the content in the liver having normal function;
• expressing the tendency of change for all of the marker substances measured as a total numerical score;
• and
• comparing the total numerical score with a numerical threshold score and transplanting the liver for transplantation to a recipient if the total numerical score is larger than the numerical threshold score;
• wherein the numerical threshold score is set between the range of total numerical scores of normal livers and mild DCD (Donation after Circulatory Death) livers and the range of total numerical scores of severe DCD livers.