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US 12,742,782 B2Granted
Methods of determining risk of and treating cancer recurrence
AssigneeThe Regents of the University of Michigan
InventorHoward Petty
Life of this patent
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Abstract
Provided herein are systems and methods for the prediction of recurrent cancer in a subject and systems and methods for using the prediction in the treatment or prevention of cancer recurrence.
Claims9
A method comprising:
- determining intracellular localization of at least one biomarker for breast cancer recurrence in a sample comprising breast cancer cells from a subject, wherein the biomarker for cancer recurrence is selected from serine-226 phosphorylated glucose transporter type 1 (phospho-GLUT1), transketolase-like protein-1, glutathione synthetase, GTP-loaded RhoA, and RhoA, and wherein determining intracellular localization comprises:
- (1) immunostaining the sample with a primary antibody directed to the biomarker for breast cancer recurrence, and (2) imaging the sample;
- and
- predicting cancer recurrence in the subject, wherein peripheral intracellular localization of the at least one biomarker indicates recurrent cancer.
1 more element
Dependencies are inferred from the claim text.