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US 12,742,770 B2Granted
Menstrual fluid simulant
AssigneeThe Procter & Gamble Company
InventorsJan Claussen, Behzad Mohebbi, Christian Neu, Alexandra Wolf, Raffaele Graziano, Laura Bordón Viloria, Dennis Winston Woertge, Pieter Jan Maria Saveyn, Michelle Natasha Adams-Hughes, Christopher Philip Bewick-Sonntag, Marc Johan Declercq
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Abstract
The present disclosure relates to menstrual fluid simulant compositions that mimic the properties of real menstrual fluid, where the menstrual fluid simulant compositions comprise vesicle dispersions of quaternary ammonium compounds and linear polymers. The present disclosure also relates to related methods and uses.
Claims20
A menstrual fluid simulant composition comprising:
- a. from 1 to 60% by weight of the simulant composition of a vesicle dispersion of a quaternary ammonium compound of Formula (I) or Formula (II):
- {R4-m—N+—[Z—Y—R1]m}X− (I)
- [R4-m—N+—R1m]X− (II)
- wherein each R is independently selected from a hydrogen, a short chain C1-C6 group, a poly(C2-3 alkoxy) group, a polyethoxy group, or a benzyl group;
- each Z is independently selected from (CH2)n, CH2—CH(CH3)— or CH—(CH3)—CH2—;
- each Y comprises —O—(O)C—, —C(O)—O—, —NR—C(O)—, or —C(O)—NR—;
- each m is 2 or 3;
- each n is from 1 to 4;
- the sum of carbon atoms in each R1, plus one if Y is —O—(O)C— or —NR—C(O)—, is twelve to twenty-two, with each R1 being a hydrocarbyl or substituted hydrocarbyl group;
- and X− is independently selected from the group consisting of chloride, methyl sulfate, and ethyl sulfate;
- b. from 0.1% to 3% by weight of the simulant composition of a linear, nonionic polymer selected from the group consisting of polyacrylamides and polyethylene oxides, the linear, nonionic polymer having a viscosity average molecular weight (MV) greater than or equal to 100 kDA and less than 25,000 kDA;
- c. from 0.05% to 0.9% by weight of the simulant composition of an inorganic salt;
- d. from 0.1% to 2% by weight of the simulant composition of a dye;
- and
- e. water;
- wherein the menstrual fluid simulant composition has a viscosity that is shear-dependent and ranges from 10 mPas to 140 mPas, at 21° C. and a shear rate of 10 s-1.
13 more elements
A menstrual fluid simulant composition comprising:
- a. from 1 to 60% by weight of the simulant composition of a vesicle dispersion of a quaternary ammonium compound of Formula (I) or Formula (II):
- {R4-m—N+—[Z—Y—R1]m}X− (I)
- [R4-m—N+—R1m]X− (II)
- wherein each R is independently selected from a hydrogen, a short chain C1-C6 group, a poly(C2-3 alkoxy) group, a polyethoxy group, or a benzyl group;
- each Z is independently selected from (CH2)n, CH2—CH(CH3)— or CH—(CH3)—CH2—;
- each Y comprises —O—(O)C—, —C(O)—O—, —NR—C(O)—, or —C(O)—NR—;
- each m is 2 or 3;
- each n is from 1 to 4;
- the sum of carbon atoms in each R1, plus one if Y is —O—(O)C— or —NR—C(O)—, is twelve to twenty-two, with each R1 being a hydrocarbyl or substituted hydrocarbyl group;
- and X− is independently selected from the group consisting of chloride, methyl sulfate, and ethyl sulfate;
- b. from 0.1% to 3% by weight of the simulant composition of a linear, nonionic polymer selected from the group consisting of polyacrylamides and polyethylene oxides, the linear, nonionic polymer having a viscosity average molecular weight (MV) greater than or equal to 100 kDA;
- c. from 0.05% to 0.9% by weight of the simulant composition of an inorganic salt;
- d. from 0.1% to 2% by weight of the simulant composition of a dye;
- and
- e. water;
- wherein the menstrual fluid simulant composition has a filament breakup time of 100 to 3000 ms, measured using the Capillary Breakup Extensional Rheometry (CaBER) described herein.
13 more elements
A menstrual fluid simulant composition comprising:
- a. from 1% to 60% by weight of the simulant composition of a vesicle dispersion of a quaternary ammonium compound of Formula (I) or Formula (II):
- {R4-m—N+—[Z—Y—R1]m}X− (I)
- [R4-m—N+—R1m]X− (II)
- wherein each R is independently selected from a hydrogen, a short chain C1-C6 group, a poly(C2-3 alkoxy) group, a polyethoxy group, or a benzyl group;
- each Z is independently selected from (CH2)n, CH2—CH(CH3)— or CH—(CH3)—CH2—;
- each Y comprises —O—(O)C—, —C(O)—O—, —NR—C(O)—, or —C(O)—NR—;
- each m is 2 or 3;
- each n is from 1 to 4;
- the sum of carbon atoms in each R1, plus one if Y is —O—(O)C— or —NR—C(O)—, is twelve to twenty-two, with each R1 being a hydrocarbyl or substituted hydrocarbyl group;
- and X− is independently selected from the group consisting of chloride, methyl sulfate, and ethyl sulfate;
- b. from 0.1% to 3% by weight of the simulant composition of a linear, nonionic polymer selected from the group consisting of polyacrylamides and polyethylene oxides, the linear, nonionic polymer having a viscosity average molecular weights (MV) greater than or equal to 100 kDA;
- c. from 0.05% to 0.9% by weight of the simulant composition of an inorganic salt;
- d. from 0.1% to 2% by weight of the simulant composition of a dye;
- and
- e. water;
- wherein the menstrual fluid simulant composition has a surface tension that ranges from 35 mN/m to 70 mN/m.
13 more elements
Dependencies are inferred from the claim text.