Charge detection mass spectrometry using multiple accumulation events

A non-transitory computer-readable medium storing instructions that, when executed, direct at least one processor of a computing device for charge detection mass spectrometry to perform a process comprising:

• subdividing a mass-to-charge ratio (m/z) range of interest into a plurality of m/z windows;
• determining an ion population control parameter for each m/z window, wherein the ion population control parameter for each m/z window regulates a quantity of ions accumulated in an ion store during an accumulation event;
• directing accumulation, in the ion store by one or more accumulation events each corresponding to a distinct m/z window of the plurality of m/z windows, of a population of ions derived from a sample, wherein during each accumulation event ions within an m/z window corresponding to the accumulation event are accumulated in the ion store based on the ion population control parameter for the corresponding m/z window;
• directing transfer of the accumulated population of ions to a mass analyzer;
• and
• directing mass analysis of the population of ions to acquire a CDMS spectrum of the population of ions.

A system for charge detection mass spectrometry (CDMS), comprising:

• an ion store that accumulates, by one or more accumulation events, a population of ions derived from a sample;
• a mass analyzer that acquires, by CDMS, a mass spectrum of the accumulated population of ions after the accumulated population of ions is transferred to the mass analyzer;
• a mass filter that selectively transmits ions derived from the sample based on m/z of the ions;
• and
• a computing device configured to perform a process comprising:
• subdividing a mass-to-charge ratio (m/z) range of interest into a plurality of m/z windows, wherein each accumulation event of the one or more accumulation events corresponds to a distinct m/z window of the plurality of m/z windows;
• determining an ion population control parameter for each m/z window, wherein the ion population control parameter for each m/z window regulates a quantity of ions accumulated in the ion store during a corresponding accumulation event;
• and
• directing accumulation, in the ion store by the one or more accumulation events, of the population of ions derived from the sample, wherein during each accumulation event ions within an m/z window corresponding to the accumulation event are accumulated in the ion store based on the ion population control parameter for the corresponding m/z window.