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US 12,742,182 B2Granted
Cytokine immunotherapy
AssigneeVLP Therapeutics, LLC
InventorsWataru Akahata, Jonathan F. Smith
Life of this patent
Estimating the term…
Abstract
Provided herein is a novel immunologically-active alphavirus replicon vector which comprises a nucleic acid encoding alphavirus nonstructural proteins nsp1-4 and a cytokine protein(s)/polypeptide(s), which is useful for the treatment of a cancer and/or an inflammatory disease.
Claims18
An alphavirus replicon vector comprising, a polynucleotide which encodes (i) VEEV non-structural proteins nsp1, nsp2, nsp3 and nsp4, and (ii) a polypeptide comprising a cytokine which has the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.