Specific host factor of hepatitis B virus infection, and use thereof
AssigneeNational Institute of Biological Sciences, Beijing
InventorsCong Li, Yixue Wang, Wenhui Li
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Abstract
Provided is a host factor specific for hepatitis B virus (HBV) infection. The specific host factor CREBH can remarkably enhance HBV infection. The specific host factor can, on the one hand, enhance entry of HBV, and on the other hand, enhance transcription of HBV to some extent. In the CREBH regulatory pathway there is a specific host factor SCARF2. During HBV infection, an N-terminus EGF-like domain of SCARF2 plays a crucial role in the infection and entry of HBV. The two correlated specific host factors provide a new target for inhibiting HBV infection.
Claims6
A cell expressing a truncated form of a first exogenous host factor specific for hepatitis B virus (HBV) infection, wherein the truncated form comprises an N-terminus domain of the first exogenous host factor, and wherein the truncated form of the first exogenous host factor consists of an amino acid sequence as shown in SEQ ID NO:
- 9 or 10.
Dependencies are inferred from the claim text.