Antibodies targeting glioblastoma stem-like cells and methods of use thereof
AssigneeWisconsin Alumni Research Foundation
InventorsMichael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
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Abstract
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
Claims20
A nucleic acid construct comprising a polynucleotide, wherein the polynucleotide encodes a chimeric antigen receptor (CAR) polypeptide, and the CAR polypeptide comprises an extracellular domain, wherein the extracellular domain comprises a glioblastoma stem-like cell binding domain or an antigen-binding fragment thereof, wherein the glioblastoma stem-like cell binding domain comprises a CDR1 domain comprising SEQ ID NO:3, a CDR2 domain comprising SEQ ID NO:4, and a CDR3 domain comprising SEQ ID NO:5.
Dependencies are inferred from the claim text.