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AssigneesInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences, National Center for Nanoscience and Technology
InventorsHaiyan Xu, Chen Wang, Shilin Xu, Yanlian Yang, Jie Meng, Jian Liu, Tao Wen
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The invention discloses a polypeptide that specifically binding to CD123 protein, a polypeptide complex and a co-delivery system, and preparation methods and use thereof. The general formula of amino acid arrangement in the polypeptide is X1-DYDTR-X2-QGTD-X3-G-X4-DFRRISD-X5; it can bind to CD123-positive cells and inhibit the progression of leukemia; the polypeptide complex can increase the binding quantity of the polypeptide to CD123-positive cells, and drug can inhibit the progression of leukemia alone and prolong the survival of leukemia mice; the co-delivery system can load chemotherapy drugs for tumor treatment and reduce the toxicity of chemotherapy drugs to normal cells.
An isolated polypeptide that specifically binds to a CD123 protein, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of:
A polypeptide complex that specifically binds to a CD123 protein, wherein the polypeptide complex is prepared from raw materials including 1 pant by weight of the polypeptide of claim 1 and 1-50 parts by weight of a macromolecular material.
A method for treating a CD123-positive leukemia in a subject, the method comprising administering an effective amount of a polypeptide, a polypeptide complex, or a co-delivery system to the subject;
Dependencies are inferred from the claim text.