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US 12,742,014 B2Granted
Liquid pharmaceutical composition comprising an anti-il-6 receptor antibody
AssigneeFresenius Kabi Deutschland GmbH
InventorsAlessandra Del Rio, Carmela Sabina
Life of this patent
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Abstract
The present invention relates to a novel protein formulation. In particular, the invention relates to a liquid pharmaceutical composition of an antibody directed to Interleukin-6 receptor, a method of manufacturing the composition, a kit including the composition, a package including the composition and to methods of treatment using the composition and/or package.
Claims14
A liquid pharmaceutical composition consisting of:
- (a) tocilizumab;
- (b) an histidine buffer;
- (c) a polyol;
- (d) a free amino acid;
- (e) a surfactant;
- (f) water for injection;
- and
- (g) optionally a salt;
- wherein the composition has a pH between 5.5 and 7.5.
6 more elements
A liquid pharmaceutical composition consisting of:
- (a) tocilizumab;
- (b) an histidine buffer;
- (c) a polyol;
- (d) a free amino acid;
- (e) a surfactant;
- and
- (f) water for injection;
- wherein the composition has a pH between 5.5 and 7.5.
5 more elements
A liquid pharmaceutical composition consisting of:
- (a) tocilizumab;
- (b) an histidine buffer;
- (c) a polyol;
- (d) a surfactant;
- (e) water for injection;
- and
- (f) a salt, wherein the salt is the salt form of a free amino acid;
- wherein the composition has a pH between 5.5 and 7.5.
5 more elements
Dependencies are inferred from the claim text.