Humanized anti-TrkA antibodies and uses thereof

A humanized antibody or antigen-binding fragment thereof capable of specifically recognizing TrkA, wherein the antibody or antigen-binding fragment thereof comprises:

• a heavy chain variable region with the VH-CDR1 shown in SEQ ID NO:41, the VH-CDR2 shown in SEQ ID NO:42 or SEQ ID NO:43, and the VH-CDR3 shown in SEQ ID NO:
• 44;
• a light chain variable region with the VL-CDR1 shown in SEQ ID NO:45, the VL-CDR2 shown in SEQ ID NO:46 or SEQ ID NO:47, and the VL-CDR3 shown in SEQ ID NO:48;
• a heavy chain framework region sequence;
• and
• a light chain framework region sequence;
• wherein the heavy chain framework region sequence and the light chain framework region sequence are derived from human IgG antibodies or mutants thereof.