Human IL-33 antibodies, preparation method and conjugates thereof and method of use thereof for treatment
AssigneeSunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
InventorsWei Guo, Xuesai Zhang, Huiting Xu, Qingrou Li, Le Zhao, Jianhe Chen, Haomin Huang, Zhenping Zhu
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Abstract
The present invention relates to an antibody binding to human IL-33 or an antigen-binding fragment thereof, which can bind to the human IL-33 with a high affinity and block the binding of ST2 to IL-33, can be used in the preparation of a drug for treating diseases with a high IL-33 expression (such as asthma, atopic/allergic dermatitis, chronic rhino sinusitis and chronic obstructive pulmonary diseases (COPD)), and has good clinical application prospects.
Claims19
A human IL-33 antibody or antigen-binding fragment thereof comprising:
- (a) heavy chain complementarity determining regions H-CDR1, H-CDR2, and H-CDR3, having the amino acid sequences of SEQ ID NO:
- 15, 16, and 17, respectively, SEQ ID NO:
- 18, 19, and 20, respectively, or SEQ ID NO:
- 18, 24, and 25, respectively, and
- (b) light chain complementarity determining regions L-CDR1, L-CDR2, and L-CDR3, having the amino acid sequences of SEQ ID NO:
- 21, 22, and 23, respectively, SEQ ID NO:
- 26, 22, and 27, respectively, or SEQ ID NO:
- 26, 22, and 28, respectively.
Dependencies are inferred from the claim text.