Back to results
US 12,742,004 B2Granted
Pharmaceutical composition containing antibody against IL-5 and use thereof
AssigneesJiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
InventorsTingting Wu, Hao Li, Xun Liu, Weikang Tao
Life of this patent
Estimating the term…
Abstract
Disclosed in the present application are a pharmaceutical composition containing an antibody against IL-5 and use thereof. In particular, disclosed in the present application is a pharmaceutical composition, which contains an IL-5 antibody or an antigen binding fragment thereof in a buffer solution. In addition, the pharmaceutical composition further contains a saccharide and a nonionic surfactant.
Claims20
A pharmaceutical composition, comprising:
- (a) an anti-IL-5 antibody or an antigen-binding fragment thereof wherein, the anti-IL-5 antibody or the antigen-binding fragment thereof comprises a heavy chain variable region comprising HCDR1, HCDR2 and HCDR3 as shown in amino acid sequence SEQ ID NOs:
- 16, 17 and 18, respectively, and a light chain variable region comprising LCDR1, LCDR2 and LCDR3 as shown in amino acid sequence SEQ ID NOs:
- 19, 20 and 21, respectively;
- (b) a buffer, wherein the buffer is acetic acid-sodium acetate or succinic acid-sodium succinate buffer, the pH of the buffer is 5.0 to 6.5, the concentration of the buffer is 10 mM to 40 mM;
- (c) a surfactant, wherein the surfactant is polysorbate 80, the concentration of the polysorbate 80 is 0.1 mg/ml to 0.6 mg/ml;
- (d) a stabilizer, wherein the stabilizer is sucrose, the concentration of the sucrose is 50 mg/ml to 80 mg/ml.
3 more elements
Dependencies are inferred from the claim text.