Insulin-Fc fusion proteins and methods of use to treat cancer
AssigneeAkston Biosciences Corporation
InventorsTodd C. Zion, Thomas M. Lancaster
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compositions of fusion proteins, e.g., insulin-Fc fusion proteins, and their use to treat cancer cells and cancer tumors.
Claims10
A fusion protein for use in treating cancer, said fusion protein comprising an insulin polypeptide and an Fc fragment, wherein the fusion protein comprises the sequence:
- (SEQ ID NO:
- 18)
- FVNQHLCGSDLVEALALVCGERGFFYTDPTGGGPRRGIVEQCCHSICSL
- YQLENYCNGGGGAGGGGAGGGGDKTHTCPPCPAPELLGGPSVFLFPPKP
- KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY
- NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE
- PQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTT
- PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
- SPG,
- and wherein the ratio of IC50 for the fusion protein to IC50 for recombinant human insulin (RHI) is less than or equal to 20.
A pharmaceutical composition for inhibiting cancer cell metabolism, growth, and/or proliferation, said composition comprising a fusion protein dispersed in a pharmaceutically acceptable carrier, wherein the fusion protein comprises the sequence:
- (SEQ ID NO:
- 18)
- FVNQHLCGSDLVEALALVCGERGFFYTDPTGGGPRRGIVEQCCHSICSL
- YQLENYCNGGGGAGGGGAGGGGDKTHTCPPCPAPELLGGPSVFLFPPKP
- KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY
- NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE
- PQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTT
- PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
- SPG.
A method of inhibiting cancer cell metabolism, growth, and/or proliferation, said method comprising administering an effective amount of a fusion protein to a mammal in need thereof, said fusion protein comprising the sequence:
- (SEQ ID NO:
- 18)
- FVNQHLCGSDLVEALALVCGERGFFYTDPTGGGPRRGIVEQCCHSICSL
- YQLENYCNGGGGAGGGGAGGGGDKTHTCPPCPAPELLGGPSVFLFPPKP
- KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY
- NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE
- PQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTT
- PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
- SPG.
Dependencies are inferred from the claim text.